It was as a poet that Ephrem made his greatest impact. Writing in isosyllabic verses called madrashe, he attained a literary brilliance that won him a place of prominence not only in his own tradition, but also in the Coptic, Ethiopian, Armenian, and Arabic traditions as well. His hymns, praised in the West by Jerome, had a formative influence on the development of medieval religious drama in Europe. Blending Greek forms with his native style, he wove a highly crafted poetry of rich symbolism, attempting to fit the events of his day into a cosmic framework of God's redemptive act in Christ. Ephrem's combination of elements of Stoicism and Middle Platonism with Christian belief in a form reminiscent of the great second century apologists produced a corpus that speaks of his own literary genius and even more eloquently of the majesty and beauty of the divine source of all true poetry.

Here, in a fresh and lively translation, are the Hymns on the Nativity, Hymns Against Julian, and the Hymns on Virginity and the Symbols of the Lord in which that voice may be heard closely and appreciated, wondered at, and enjoyed.